PHR 1114 - Drug Delivery Systems

4 Credit Hours

This course will emphasize the physico-chemical principles that underlie the pre-formulation, formulation, manufacturing, compounding and dispensing of commonly used pharmaceutical dosage forms. These principles include considerations of pKa and molecular structure, pH, buffer solutions, thermodynamics, solubility in aqueous and non-aqueous phases, isotonicity, chemical stability and physical stability. Solid, semi-solid, dispersed, liquid and aerosol delivery systems will be discussed. Formulation, dispensing, production and quality requirements of parenteral products will be introduced. The formulation and stability characteristics of biotechnology products which are primarily IV solutions and suspensions will be illustrated. Concepts and technologies for extemporaneous compounding of specialty pharmaceuticals such as dermatologicals, radio-pharmaceuticals and veterinary products will be discussed.

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